|
KMID : 0939920070390010000
|
|
대한암학회지
2007 Volume.39 No. 1 p.0 ~ p.0
|
|
|
A Phase II Study of Paclitaxel and Cisplatin as Salvage Therapy for Patients with Advanced or Metastatic Gastric Cancer
|
|
Seo Bong-Gun
Oh Sung-Yong
Lee Dong-Mee
Yoo Hyun-Sung
Lee Suee
Kim Seong-Geun
Kim Sung-Hyun
Kwon Hyuk-Chan
Kim Hyo-Jin
|
|
|
Abstract
|
|
|
Purpose:To evaluate the therapeutic activity and safety of paclitaxel and cisplatin combination chemotherapy in patients with advanced or metastatic gastric cancers that are unresponsive to primary chemotherapy.
Materials and Methods:Advanced or metastatic gastric cancer patients unresponsive to first line chemotherapy were entered into this trial. The treatment regimen consisted of paclitaxel, 175 mg/m2 by 3-hour infusion on day 1, and cisplatin, 60 mg/m2 by 1 hour infusion on day 1, with the treatment repeated every 3 weeks.
Results:37 patients were entered in this study, with 32 fully evaluable for response. 4 (13%), 13 (40%) and 15 (47%) patients achieved a partial response, stable disease and progressed, respectively. The median time to progression was 4.0 months (95% CI: 2.0∼6.0 months), and the median overall survival was 12.6 months (95% CI: 5.5∼19.7 months), with a 1-year survival rate of 54%. Of a total of 135 cycles of chemotherapy, grades 3 and 4 hematological toxicities were neutropenia (14%) and anemia (3%). Grade ≥2 neuropathy was observed in 6 patients (17%).
Conclusion:The combination of paclitaxel and cisplatin is an effective and tolerable salvage treatment modality for advanced gastric cancer.
|
|
|
KEYWORD
|
|
|
Paclitaxel, Cisplatin, Salvage, Advanced gastric cancer
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
    
|
|